Non-Invasive Deep Brain Stimulation

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Neuropsychiatric disorders like Obsessive Compulsive Disorder (OCD) and depression disrupt the lives of millions of people in the world. State-of-the-art methods for treatment are mainly based on behavior therapy and medications, which may not be widely effective for various types of disorders and can be even risky to patients. The Rice team is performing modeling and simulations for both the low intensity focused ultrasound (LIFU) and millimeter wave (mmWave) arms of the non-invasive DBS project. For LIFU, work will involve detailed computational modeling of how the stimulation transducer pulses traverse biological media (e.g., skull, brain) together with how pulses from multiple transducers interact to produce a focused modulation of the targeted anatomic structure in a safe, controlled manner. Parallel modeling with similar aims will be conducted for the mmWave approach. Work will also involve validating the modeling for LIFU and mmWave approaches in the form of hardware implementation using phantom and animal models.

Collaborators: Wayne Goodman M.D., Raymond Cho M.D. and Sameer Sheth M.D.

Current Student Researchers: Fatima Ahsan and Boqiang Fan

Funded By:

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